Recent study has found that ox-LDL transforms into a glycolytic phenotype by promoting metabolism and inducing cytoprotective autophagy, thereby making pancreatic cancer cells resilient or resistant (118) LOX-1 can up-regulate the expression of c-Myc, and the transcription of high mobility group AT-hook 2 (HMGA2). The gene discussed is HMGA2; the disease is familial pancreatic carcinoma.