It is known that diet-induced hypercholesterolemia increases the expression of LOX-1 in renal arterioles, and subsequently facilitates the uptake and cytotoxicity effects of ox-LDL (144) Ox-LDL enhanced the LOX-1 expression in tubular epithelial cells in a dose-dependent manner within a certain concentration range and mediates EMT progression in rat renal tubular epithelial cells NRK-52E. Here, OLR1 is linked to familial hypercholesterolemia.