CD226 and breast cancer: LDL also promotes the progression and metastasis of breast cancer through Akt-induced EMT and angiogenesis, increases the levels of mesenchymal markers Slug, vimentin, and β-catenin, and decreases in expression of adhesion molecules (cadherin-related family member3(CDHR), CD226, Claudin 7 and Ocludin), thereby promoting the migration and invasion of breast cancer cells (48, 83).