Beyond in vitro studies, Gallagher et al. found that elevated LDLR expression in tumor accelerated LDL-C-mediated breast cancer growth in hyperlipidemic mice, In contrast, LDLR silencing and lower circulating levels of LDL-C retard tumor growth in HER2 positive and triple-negative breast cancer mouse models (84). This evidence concerns the gene ERBB2 and breast carcinoma.