PTGS2 and cancer: ω-6 PUFAs bind to COX-2 in the human body to generate PGE2, while PGE2 can induce cell proliferation and stimulate the expression of BLC-2 protein (BLC-2 protein inhibits apoptosis) to imbalance cell proliferation and apoptosis and promote the occurrence of tumors; PGE2 can also promote extracellular matrix degradation and produce thromboxane to promote platelet aggregation, which is conducive to the invasion and metastasis of cancer cells.