The bioluminescence intensity of Arg1EP-Luciferase-GFP/Raw264.7 cells also increased significantly when cultured in the presence of IL-4 compared to the untreated controls, while bioluminescence intensity of Arg1 macrophages co-incubated with Hepa1-6 was the strongest in the tumor microenvironment. This evidence concerns the gene IL4 and neoplasm.