identified antibodies specific to 11 TAAs, including TP53, MSH2, mouse G-protein α subunit (GNAS), Pten, mouse pile-protein 5 (PAX5), GNA11, mouse patching homologue (PTCH), IDH1, SRSF2, mouse nucleolar phosphate 1 (NPM1) and Survivin by screening the sera of a large number of liver cancer patients. The gene discussed is NPM1; the disease is liver cancer.