The mechanisms of metabolic symbiosis in cancer have been proposed based on the expression levels of enzymes and transporters, such as glucose transporter 1 (GLUT1) and monocarboxylate transporter 1 (MCT1) and 4 (MCT4), in cancer cells and CAFs as determined immunohistochemical analyses (26, 31–33). This evidence concerns the gene SLC16A1 and cancer.