Analysis of the ENSG00000130821 dataset in the EWAS Data Hub online database showed that methylation levels in LUAD (Figure 5A; Supplementary Material 1) and LUSC (Figure 5B; Supplementary Material 2) negatively correlated with SLC6A8 expression, and the methylation levels in tumor tissues were lower than those in normal tissues. The gene discussed is SLC6A8; the disease is neoplasm.