In addition, cg12177562, cg13762255 and cg20765985 methylation sites had significantly poorer OS in the low expression group compared to the high expression group in both lung adenocarcinoma and lung squamous carcinoma.As these sites were significantly negatively correlated with SLC6A8 expression in lung adenocarcinoma and lung squamous carcinoma, these three sites may be potential therapeutic targets for modulating the poor prognosis of SLC6A8 in NSCLC. Here, SLC6A8 is linked to lung adenocarcinoma.