EMT is known to play a central role in inducing resistance of tumor cells to irradiation, and it is regulated by a variety of molecular mechanisms containing TGF-β, Wnt/β-catenin, PI3K/AKT, Notch, NF-κB, IL-6/STAT3, non-coding RNAs and so on. The gene discussed is TGFB1; the disease is neoplasm.