In addition to common regulatory events, SKOV-3 and OVCAR-3 displayed also an individual signature; in OVCAR-3 physical stress lead to a significant downregulation of the beta-galactosidase (GLB1, Figure 7B) and upregulation of STUB1 [involved in protein ubiquitination and quality control, (85)], LSS (lanosterol synthase) and MEMO1, the latter was already describe to play an important role in cancer cell motility (86). The gene discussed is STUB1; the disease is cancer.