TP53 and cancer: In this respect, casein kinase 2 can drive metabolism of cancer cells via manifold interactions including i) Wnt/β-catenin, ii) PI3K/Akt/mTORC1, and iii) p53/HIF-1α (108); all these elements were significantly regulated in our models, possibly supporting the interpretation that hypoxia could foster the abovementioned metabolic levers.