ESRRA and neoplasm: In line with the adaptive response of OVCAR-3 to hypoxia, we also observed modulation of several transcription factors, such as TAF1 [regulator of cell cycle (78), downregulated] the aryl hydrocarbon receptor nuclear translocator (ARNT, already reported as tumor growth promoter (79), upregulated) and the steroid hormone receptor ERR1 (ESRRA, downregulated; Supplementary Figure S7).