ERBB2 and ovarian carcinoma: In line with the results of the bioinformatics pipeline we detected the phosphorylation of the receptor tyrosine-protein kinase erbB-2, which was previously identified as one of the key elements of the hypoxia signature in ovarian cancer cells (23), and of the membrane protein pleckstrin homology-like domain family B member 2 (PHLDB2), which is a known substrate for the protein kinase C (57).