In a recent metanalysis of 12 RCTs on the effect of berberine on PCOS patients, it was reported that berberine improved reproductive hormones (TT, SHBG, LH, LH/FSH ratio), lowered fasting and post-prandial blood glucose, and improved lipid profile as compared to placebo/no treatment [13]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.