Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinopathy characterized by irregular menstruation, infertility, hyperandrogenemia, acanthosis nigricans, and a biochemical profile showing increased luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, increased androgen levels, hyperinsulinemia, dyslipidemia, and obesity. The gene discussed is BRD2; the disease is polycystic ovary syndrome.