ERBB2 and obesity due to melanocortin 4 receptor deficiency: Tumor size, histological type, extensive intraductal component, high grade, human epidermal growth factor receptor 2 (HER2) positivity, lymph node positivity, dense breast tissue, obesity, microcalcifications on mammography (MMG), and multifocality are significant risk factors affecting the positive surgical margin in breast cancer [12].