TG and hypothyroidism: Unadjusted comparison of patients who were treated with LT4 with those who were not, showed a slightly lower rhGH dose in the first group, which might be in line with the hypothesis that best responders to rhGH are also more prone to thyroid hormone variations; this is also in agreement with Wong et al. [25], who evaluated patients with multiple GHD etiologies and reported lower doses of rhGH in patients who developed hypothyroidism.