Variation of auxological and biochemical parameters in the first two years of rhGH treatment also did not associate with hypothyroidism (Ht SDS variation 1.14 [0.68-1.2] vs 0.91 [0.61-1.61], p=0.841; GV SDS variation 3.3 ± 1.24 vs 4.4 ± 5.61, p=0.785; IGF-1 SDS variation 2.2 ± 1.43 vs 2.5 ± 1.57, p=0.729; FT4 variation -0.1 ± 0.19 vs -0.1 ± 0.18 ng/dL, p=0.869; TSH variation -1.0 ± 1.86 vs -0.8 ± 1.13 μU/L, p=0.737). The gene discussed is IGF1; the disease is hypothyroidism.