We also compared the gut mycobiota of RA patients with different disease activity parameters, including inflammatory markers (C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)), rheumatoid factor (RF), immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin E (IgE), and also tumor markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA)19-9 (CA19-9), CA125). The gene discussed is CD40LG; the disease is rheumatoid arthritis.