GLP1R and obesity due to melanocortin 4 receptor deficiency: Furthermore, the T2DM and non-T2DM groups have significantly different GLP-1 levels, as shown in the present study: in patients with obesity but without the established diagnosis of T2DM, the GLP-1 level was higher than that in healthy individuals and the values in patients with obesity and T2DM were lower than those in healthy individuals.