In 2008, Chesi and co-workers reported a murine C57BL/6-derived Vk*MYC MM preclinical model characterized by low proliferation of monoclonal plasma cells (PCs) within the Vk*MYC mice BM and secondary lymphoid organs, and therefore more closely resembling the feature of monoclonal gammopathy of undetermined significance (MGUS)/MM. This evidence concerns the gene MYC and monoclonal gammopathy.