PANK2 and pantothenate kinase-associated neurodegeneration: QSM has been used to quantify iron deposition in several different BG ROIs in order to differentiate between homozygous and heterozygous PANK2 mutations: heterozygous and asymptomatic PANK2 mutation carriers did not present higher brain iron concentrations than controls, while iron deposition 3 times higher in the GP, SN, and internal capsule of PKAN patients [136].