In non-small cell lung cancer, Xu et al. conducted TGF-β-1-induced EMT experiments and EGF-stimulated ERK1/2 activation and other related experiments confirmed that ENO1 inhibits ERK1/2 phosphorylation to inhibit the EMT process, thereby inhibiting tumor development and metastasis [40]. This evidence concerns the gene EGF and non-small cell lung carcinoma.