The GSEA results presented here showed that QPRT expression was related to the PI3K/Akt signalling pathway, and western blot analysis showed that overexpression of QPRT can increase the phosphorylation levels of PI3K and Akt, indicating that QPRT and the PI3K/Akt signalling pathway may have a positive feedback effect in breast cancer. The gene discussed is QPRT; the disease is breast carcinoma.