SYCP3 and colorectal carcinoma: It was reported that SYCP3 expression can be induced in the colorectal carcinoma cell line DLD1 after treatment with the demethylating agent 5-azacytidine, indicating that SYCP3 expression in mitotic cells is regulated by a demethylation-dependent process, similarly to other meiotic genes (Hosoya et al., 2012).