HORMAD1 and cancer: However, many studies have shown that HORMAD1 is significantly upregulated in several cancers where it correlates with increased genomic instability and poor patient prognosis (Adelaide et al., 2007; Watkins et al., 2015; Chen et al., 2018; Gao et al., 2018; Nichols et al., 2018; Gantchev et al., 2020).