In many cases, the detection AUROC values for altered genes were similar to those for altered pathways, e.g., for TP53 detection 0.66 (0.627–0.718, p < 0.001) and the for p53 pathway detection 0.682 (0.668–0.698, p < 0.001) in CRC or for TP53 detection 0.764 (0.694–0.8, p < 0.001) and for p53 pathway detection 0.71 (0.677–0.738, p < 0.001) in UCEC. This evidence concerns the gene TP53 and colorectal carcinoma.