Prognostically significant mutated genes were: SETD2 in PRAD with an AUROC of 0.895 (0.827–0.951, p = 0.005), PBRM1 in KIRP with the lowest AUROC 0.752 (0.571–0.939, p = 0.006) of these all and lastly NOTCH2 with the highest AUROC’s in CRC 0.934 (0.893–0.978, p < 0.001) and STAD 0.919 (0.846–0.982, p < 0.001). Here, NOTCH2 is linked to prostate adenocarcinoma.