IFNG and graft versus host disease: In the setting of GVHD, Tc17 cells were found to express high levels of multiple prototypic lineage-defining transcription factors (TFs) (e.g., RORγt and T-bet) and cytokines (e.g., IL-17A, IL-22, IFN-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-13) (93).