Consistent with this mouse study, tissue transcriptomics analysis from GVHD patients also showed no differences in T cells including CD8+ T cells, naïve CD4+ T cells, and memory CD4+ T cells between the new onset of aGVHD and SR-aGVHD, but multiple T cell-independent mechanisms were found to be related to SR-aGVHD (47). The gene discussed is CD4; the disease is graft versus host disease.