NLRP3 and graft versus host disease: Further study demonstrated that conditioning regimen-induced adenosine triphosphate (ATP) release plays a key role in MDSC dysfunction through the engagement of ATP receptors (P2x7R) and inflammasome activation of NLR family pyrin domain three (NLRP3); and inhibiting NLRP3 inflammasome activation and IL-1β secretion resulted in GVHD amelioration (157).