In this work, we build upon our previous observations that GM3-targeted liposomes are effectively taken up by CD169-expressing human and mouse cells (48, 49, 58, 59), and that antigen-containing GM3 liposomes together with a strong soluble adjuvant (aCD40 and poly IC) can elicit potent immune activation and anti-tumor responses (48, 49). The gene discussed is SIGLEC1; the disease is neoplasm.