This conclusion differs from a recent report that describes a haploinsufficient heterozygous mutation in GLI3 in a subpopulation of congenital mastocytosis with Greig cephalopolysyndactyly syndrome and implicates the canonical HH-pathway in aggressive mastocytosis and cultured neoplastic mast cells (16). This evidence concerns the gene GLI3 and Greig cephalopolysyndactyly syndrome.