Mice harboring a single point mutation in the Rc3h1 gene that exchanges methionine 199 to arginine (M199R) in the Roquin-1 protein develop a severe systemic lupus erythematosus-like (SLE-like) phenotype, showing deregulation of the immune system and production of anti-nuclear antibodies (ANAs), a phenotype which can be also found in the Regnase-1 KO mouse (38, 39, 45). The gene discussed is ZC3H12A; the disease is systemic lupus erythematosus.