As both protective and detrimental effects were linked to PD-L2 activation and deficiency in murine sepsis models (34), further data are needed to elucidate the functional impact of the PD-1/PD-L2 interaction and potential PD-1-independent immunomodulatory effects of PD-L2 (35) on the pathogenesis of mucormycosis. This evidence concerns the gene PDCD1 and Zygomycosis.