Supernatant of tumor cells treated with CaP-NPs was collected for measurement by ELISA and cells were analyzed by flow cytometry to determine expression of tumor cell stress ligand MIC-A (Figure 4A), ULBP-2,5,6 (Figure 4B), MHCI (Figure 4C) and CD54 (Figure 4D). The gene discussed is MICA; the disease is neoplasm.