We cocultured NK cells and ovarian cancer cells in the presence of therapeutic anti-EGFR antibody Cetuximab and added triple-shell nanoparticles (CaP-P NPs), silica-shell nanoparticles (CaP-S NPs) as well as functionalized particles with Cetuximab bound to the surface of silica-shell-particles (CaP-S-C NPs). This evidence concerns the gene EGFR and ovarian cancer.