However, in response to TLR4 stimulation, HBX facilitates the migration of liver cancer cells by enhancing the interaction of vacuolar protein sorting 34 (VPS34) with the TRAF6-Beclin 1 (BECN1) complex (63), thereby increasing BECN1 ubiquitination and autophagy, a physiological process that contributes to HBV replication (64). Here, BECN1 is linked to liver cancer.