In response to IFN-γ and lipopolysaccharide, M1 macrophages, which secrete high levels of IL-12, inhibit tumor development (63).M2-type macrophages secrete arginase, IL-10, lipopolysaccharide, IFN-γ, inhibit CD8+ T cell proliferation, and promote tumor cell growth.M2-type markers CD204 and CD206, CCL17 and CCL18, etc. (62). Here, CD8A is linked to neoplasm.