IL1B and colitis: Furthermore, by improving IL-1β, subcutaneous nicotine administration (2 mg/kg, b.i.d.)suppressed the hyperexcitability of colonic dorsal root ganglia (L1–L2) neurons and the visceral hypersensitivity of the number of abdominal constrictions in response to an intraperitoneal injection of 0.6% acetic acid in DSS-treated male C57BL/6J mice, finally relieving acute DSS colitis (33).