Male Wistar albino rats of CLP sepsis received chronic tap water with (5 mg/kg) nicotine for 14 days and an acute injection of nicotine (30 mg/kg, i.p.)for 5 days, resulting in the recovery of histologically observed injury, lipid peroxidation, and myeloperoxidase activity and the prevention of GSH depletion, indicating that nicotine was advantageous in regulating systemic inflammation by balancing the oxidant and antioxidant systems (MPO, GSH, and MDA). The gene discussed is MPO; the disease is Sepsis.