NPPB and heart failure: In cardiac troponin I-induced female A/J mice model, nicotine (for 3 days at 12.5 mg/L, 3 days at 125 mg/L, 21 days at 12.5 mg/L, and 21 days at 125 mg/L in drinking water after the first immunization) reduced inflammatory infiltration and fibrosis by downregulating the production of IL-6 and TNF-α in splenocytes, the myocardial expression of inflammatory proteins MCP-1, IL-1β, RANTES, CCR1, CCR2, and CCR5, and the myocardial expression of MMP14, NPPB (natriuretic peptide precursor B), TIMP-1, and osteopontin, which are involved in heart failure.