In AKI patients, due to mitochondrial damage and impaired FAO metabolism, as well as decreasing peroxisome proliferation-activated receptor alpha (PPARα) activity and decreasing peroxisome PGC-1 expression, the accumulation of triglycerides in AKI patients result in obvious lipid metabolism abnormalities (216–219). The gene discussed is PPARGC1A; the disease is acute kidney injury.