NETs are accompanied with intestinal barrier dysfunction, ER stress activation and ROS production in sepsis patients, leading to increased serum intestinal fatty-acid binding protein (I-FABP) and D-lactate that positively correlates with NET formation, indicating that fatty acid and lipid metabolism might be required for neutrophil maturation during sepsis (Figure 5) (63, 119). Here, FABP2 is linked to Sepsis.