Furthermore, Western blotting result showed that PEX-3-CDCA4 inhibited the expression level of BCL2-associated X protein (Bax) and increased the expression level of B-cell lymphoma-2 (Bcl-2) and PCNA in HCC cells (Supplementary Figure S2D and S2E). The gene discussed is CDCA4; the disease is hepatocellular carcinoma.