While the CX3CL1 receptor CX3CR1 clearly impacts on CNS autoimmunity through effects on myeloid cells, its role in T cell recruitment to the brain during neuroinflammation is controversial with one study indicating no T cell intrinsic role for CX3CR1 in EAE and another study showing CX3CR1-dependent recruitment of T cells to the brain during neuroinflammation (99, 100). Here, CX3CR1 is linked to Autoimmunity.