Over the past few decades, with the discovery of anti-NMDAR encephalitis in 2007 (1), an increasing number of specific neuronal surface antibodies (NSAbs) have been discovered, including LGI1-Ab, CASPR2-Ab, AMPA1/2R-Ab, GABAR-A/B-Ab, and so on (2–5). The gene discussed is CNTNAP2; the disease is encephalitis.