To assess if reduced BAFF-R expression on B cells of CIS/MS patients was associated with abnormalities of B cell activation, BAFF-R expression on total B cells was correlated with TNF production, assessed in an 18 h culture system using the TLR7/8 agonist, R848, in the presence of a GolgiPlug agent (25, 33). Here, TNFRSF13C is linked to in situ carcinoma.