However abundance of IgG3+ CD27+/CD24low and IgM+ CXCR3+ MBC correlated weakly with EBNA IgG and VCA IgG titres respectively (Supplementary Figures 8C, D), suggesting these markers may also relate to the initial response to EBV infection. This evidence concerns the gene IGHG3 and Epstein-Barr virus infection.