However, compared with uninfected mice group, significant differences in the mRNA expression of IL-10 in jejunum, colon, and spleen (Figure 12H) and TNF-α in jejunum and spleen (Figure 12B) were observed in treated MccJ25 mice group after clinically source MDR E. coli strains infection. The gene discussed is IL10; the disease is escherichia coli infection.