AKT1 and cancer: We further determined 602 EVA1B-derived genes in CRC that were mainly correlated to immune response, tumorigenic pathways (such as PI3K-Akt signaling pathway, proteoglycans in cancer, and ECM-receptor interaction), and immune activation pathways (such as IL-17 signaling pathway, Th17 cell differentiation, cytokine-cytokine receptor interaction, Th1 and Th2 cell differentiation, antigen processing and presentation, intestinal immune network for IgA production, complement and coagulation cascades), indicative of their remarkable roles in CRC progression.