We further determined 602 EVA1B-derived genes in CRC that were mainly correlated to immune response, tumorigenic pathways (such as PI3K-Akt signaling pathway, proteoglycans in cancer, and ECM-receptor interaction), and immune activation pathways (such as IL-17 signaling pathway, Th17 cell differentiation, cytokine-cytokine receptor interaction, Th1 and Th2 cell differentiation, antigen processing and presentation, intestinal immune network for IgA production, complement and coagulation cascades), indicative of their remarkable roles in CRC progression. This evidence concerns the gene AKT1 and colorectal carcinoma.