EVA1B and cancer: Additionally, there were remarkable interactions of EVA1B-derived genes with tumorigenic pathways (such as PI3K-Akt signaling pathway, proteoglycans in cancer, and ECM-receptor interaction) and immune activation pathways (such as IL-17 signaling pathway, Th17-cell differentiation, cytokine–cytokine receptor interaction, Th1- and Th2-cell differentiation, antigen processing and presentation, intestinal immune network for IgA production, complement and coagulation cascades; Figure 6B).