We now corroborate that, in contrast, the delayed administration of t-PA, despite being able to effectively recanalize high-fibrin content thrombi resulting from the in situ thromboembolic stroke model (Figure 1), does not affect infarct volume (n=6; Figure 2A) and causes bleeding and cerebral edema because of the HT phenomenon (n=6; p<0.05; Figures 2B, C). Here, PLAT is linked to hematocrit.