-Synergism with Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL), inhibiting tumor growth in colorectal tumors in vivo-Growth arrest and apoptosis in brain tumor cells-Antiproliferative activity and synergistic effect with gemcitabine, 5-Fluorouracil (5-FU) in Pancreatic ductal adenocarcinoma (PDAC) cells. The gene discussed is TNF; the disease is brain neoplasm.