In 1997, Bosch et al. (107) showed that PtdCho is a substrate for MDR1 P-glycoprotein (PgP) in T-cell leukemia resistant cells that might be responsible for the altered lipid composition between sensitive and resistant tumor cells as well as the inefficacy of treatments based on liposome delivery (107). Here, ABCB1 is linked to T-cell leukemia.