Inter-tumoral delivery of mTORC2-deficient DCs (Rictor−/− DCs) showed pro-inflammatory properties and was associated with reduced melanoma tumor growth, increased numbers of INF-γ+ and granzyme B+ (GrB+) CD8+ TILs, and reduced frequency of immunosuppressive MDSCs within TME (161). Here, GZMB is linked to melanoma.