Thus, with regard to the many actions in which mTOR is involved, the inhibition of PI3K/Akt/mTOR holds enormous potential to bring about novel therapeutic targets or strategies for reducing cancer cells proliferation, migration, invasion, and survival and enhancing the efficacy of the tumor immunosurveillance through both the downregulation of the immunosuppressive pathways and the activation of anti-tumor immunity in combination with agents able to negate immune suppression and boost T cell immunity. Here, AKT1 is linked to cancer.