Similarly, tumor-derived granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) induces the expression of miR-200c in tumor environment, and miR-200c, in turn, enhances the expansion and immune suppressive potential activity of MDSCs through negatively targeting PTEN and friend of Gata 2 (FOG2) expression. This evidence concerns the gene PTEN and neoplasm.