In infants with history of hypoglycaemia, hyperbilirubinemia, poor growth, midline defects, microphallus, low IGF-1 and IGFBP-3, MPHD, such as TSH and ACTH deficiency, and/or an abnormal brain MRI, the diagnosis of GHD is possible without stimulation test (6) (Table 1). The gene discussed is IGFBP3; the disease is Hypoglycemia.