Uterine expression of several genes important for implantation is also altered in the uterus of mice exposed to intrauterine ghrelin deficiency, and abnormalities in endometrial proliferation have been observed (63), leading to the conclusion that exposure to reduced ghrelin in the uterus causes defects in uterine developmental programming and subsequent infertility in wild-type offspring. This evidence concerns the gene GHRL and Infertility.