<h4>Objective</h4>This systematic review and meta-analysis aimed to evaluate the effects of SGLT-2 inhibitors (SGLT-2i) on endothelial function and arteriosclerosis in diabetic patients.<h4>Methods</h4>Randomized controlled trials (RCTs) were retrieved from PubMed, Embase, Cochrane Library, and Web of Science databases to evaluate the effects of SGLT-2i on endothelial function and atherosclerosis in type 2 diabetic patients.<h4>Results</h4>We selected 9 RCTs and 2 cohort studys involving 868 patients. This evidence concerns the gene SLC5A2 and atherosclerosis.