The standardized regression coefficient from baseline hyperuricemia to subsequent development of MAFLD was β1 = 0.039 (95% CI: 0.026, 0.051), and the standardized regression coefficient from baseline MAFLD to subsequent development of hyperuricemia was β2 = 0.030 (95% CI: 0.017, 0.043) after adjusting for age, sex, LDL-C, FBG, ALT, BUN, SBP, TG, and insulin resistance. The gene discussed is GPT; the disease is Insulin resistance.