COL11A2 and early-onset non-syndromic cataract: In the 2 patients with type XI collagen gene mutation, besides the typical skeletal and orofacial manifestations, P.22 with COL11A1 missense mutation showed a less severe ocular presentation, while the boy with a COL11A2 splice site alteration presented with obvious ocular anomalies of congenital cataracts.