In addition, two loci (index SNPs: rs72712556 and rs10030552) mapped to MAML3 were found to have genome-wide significance in the meta-analysis of smoking status–T2D and smoking status–HF, which reached genome-wide significance in the single-trait GWAS of smoking status, but its association with HF or T2D remains unknown and deserves in-depth study. Here, MAML3 is linked to type 2 diabetes mellitus.