No differences between unilateral PA and IHA groups were found in gender, center of diagnosis, age at diagnosis of PA, duration of hypertension, weight, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), number of antihypertensive drugs, sodium, PRA, lesion size and right/left CSI (Table 1). This evidence concerns the gene S100A6 and hypertensive disorder.