And there is a randomized controlled trial using BNZ-1, a selective and simultaneous inhibitor of cytokines IL-2, IL-9, and IL-15, for the treatment of hyperandrogen-induced hair loss (57).It shows that factors that inhibit IL-15 such as BNZ-1 have a role in the treatment of PCOS hyperandrogenism. This evidence concerns the gene IL2 and hyperandrogenism.