To conclude, whereas it is clear that adipocyte PPARγ deficiency leads to severe lipodystrophy, the FPLD phenotype due to P465L is not easy to recapitulate in mice and it appears that according to the body weight phenotype (lean, mild overweight or obese), this mutation will balance towards healthy leanness or lipoatrophic insulin resistant phenotype. This evidence concerns the gene INS and lipodystrophy.