CAV1 and Insulin resistance: Despite normal AT depots at birth, caveolin-1 null mice display a progressive lipoatrophy aggravating with age, although developing with a slightly different time frame depending on the KO model considered, characterized by the loss of hypodermal fat layer and generalized reduction of all WAT depots, hypertriglyceridemia but very mild insulin resistance as soon as 3 months of age (54, 57).