CEBPA and lipodystrophy: A few years later, three mouse models of generalized lipodystrophy have been generated by modifying the expression of key transcription factors involved in adipogenesis: the adipocyte-specific over-expression of the nuclear mature form of SREBP1c (aP2-nSREBP1c) (8), the adipocyte specific expression of a dominant negative protein that binds to C/EBPα (A-ZIP/F mice) (9) and the suppression of C/EBPα expression in the AT (10).