Pathogenic variants in KCNT1, also encoding a potassium channel, are responsible for a broad phenotypic spectrum that include autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), early-onset epileptic encephalopathy (EOEE), and epilepsy of infancy with migrating focal seizures (EIMFS) in neonates and infants, which are often refractory to conventional ASMs (49). The gene discussed is KCNT1; the disease is epilepsy.