GH1 and cancer: The clinical guidelines for children patients treated with GH were summarized from the Pediatric Endocrine Society (USA): (i) GH can be safely administered to children without inducing any known risk factor; (ii) in children with known predisposing conditions, GH therapy should be assessed on an individual basis and properly monitored (iii) for children who are cancer survivors in remission, GH can be administered with the understanding that it can enhance the risk of a second malignancy (57).