Previous study has shown that IGF-1 could reverse the electrophysiological deficits observed in Shank3-deficient mice and the induced pluripotent stem cells (iPSCs) from patients with PMS, indicating that IGF-1 could strengthen excitatory synaptic transmission and reduce the rate of NMDA-receptors decay (3, 12, 14). Here, SHANK3 is linked to premenstrual tension.