APOE and atherosclerosis: It was also previously reported that progression of atherosclerosis induces characteristic mechanical, morphological, and physiological RBC alterations (Kanakaraj and Singh, 1989; Van Zwieten et al., 2012; Unruh et al., 2015; Dybas et al., 2020), but yet, the impact of sex has not been investigated in ApoE-LDLR double-deficient (ApoE/LDLR−/−) mice.